Bioactive Small Molecules
Medchemexpress LLC Ansornitinib | 1448874-96-1 | 98.2% | 540.61 | 100 MG
Ansornitinib is an orally active dual kinase inhibitor that inhibits platelet-derived growth factor receptor (PDGFR) and vascular endothelial growth factor receptor (VEGFR2). It can be used as an antifibrotic agent in lung, liver, kidney, and gastrointestinal fibrotic diseases.
- Orally active dual kinase inhibitor
- Inhibits platelet-derived growth factor receptor (PDGFR)
- Inhibits vascular endothelial growth factor receptor (VEGFR2)
- Functions as an antifibrotic agent
- Significantly inhibits phosphorylation of PDGFRβ and KDR
- Reduces inflammation and fibrosis markers
- Shown to reduce lung fibrosis in animal models
- Improves colonic histology in animal models
Selleck Chemical LLC LY3009120
LY03009120 (DP-4978) is a potent pan-Raf inhibitor with IC50 of 44 nM 31-47 nM and 42 nM for A-raf B-Raf and C-Raf in A375 cells respectively LY03009120 induces autophagy Phase 1
Selleck Chemical LLC Ginsenoside Rg5 E2459-1MG
Ginsenoside Rg5 the main component of Red ginseng blocks binding of IGF-1 to its receptor with an IC50 of 90 nM Ginsenoside Rg5 also inhibits the mRNA expression of COX-2 via suppression of the DNA binding activities of NF- B p65
Selleck Chemical LLC GNE-049
GNE-049 is a highly potent and selective inhibitor of CBP It exhibits an IC50 of 1 1 nM in TR-FRET assay GNE-049 also effectively inhibits BRET and BRD4 with IC50 values of 12 nM and 4200 nM respectively
Medchemexpress LLC Emd534085 | 858668-07-2 | 99.6% | 476.53 | 50 MG
Emd534085 | 858668-07-2 | 99.6% | 476.53 | 50 MG
Medchemexpress LLC SKLB-11A | 433953-86-7 | 99.4% | 350.35 | 25 MG
SKLB-11A | 433953-86-7 | 99.4% | 350.35 | 25 MG
Cayman Chemical ANTIBODY MItoquInol 5mg
A mitochondria-targeted antioxidant; reduces hydrogen peroxide production in succinate-fueled isolated bovine aortic endothelial mitochondria
Medchemexpress LLC HY-A0063 10mg , Tipiracil (hydrochloride) CAS:183204-72-0 Purity:>98%
HY-A0063 10mg Tipiracil (hydrochloride) CAS: 183204-72-0 Tipiracil (hydrochloride) is a thymidine phosphorylase inhibitor (TPI), used for cancer research. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical 8-AmInoclonazolam 5mg
An analytical reference standard categorized as a benzodiazepine metabolite; a metabolite of clonazolam; intended for research and forensic applications
Sigma Aldrich Fine Chemicals Biosciences Dorzolamide hydrochloride British Pharmacopoeia (BP) Reference Standard | 130693-82-2 | MFCD00884659 |
Dorzolamide hydrochloride British Pharmacopoeia (BP) Reference Standard | Mol Wt: 360.9 | 130693-82-2 | MFCD00884659 |
Medchemexpress LLC HY-19331 10mg , WZB117 CAS:1223397-11-2 Purity:>98%
HY-19331 10mg WZB117 CAS: 1223397-11-2 WZB117 is a glucose transporter 1 (Glut1) inhibitor, which downregulates glycolysis, induces cell-cycle arrest, and inhibits cancer cell growth in vitro and in vivo. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Teneligliptin | 760937-92-6 | 99.8% | 426.58 | 250 MG
Teneligliptin hydrobromide hydrate is an orally active and selective dipeptidyl peptidase 4 (DPP-4) inhibitor with IC50s of 0.37 and 0.29 nM for human and rat DPP-4, respectively. It improves blood glucose levels and is used in research related to type 2 diabetes mellitus. It is for research use only and not sold to patients.
- Orally active and selective dipeptidyl peptidase 4 (DPP-4) inhibitor
- Improves blood glucose levels
- Used in research related to type 2 diabetes mellitus
- For research use only
Medchemexpress LLC JNJ-28583113 | 2765255-93-2 | >98.8% | 366.38 | 250 MG
JNJ-28583113 is a brain-permeable TRPM2 antagonist. It inhibits TRPM2-blocked phosphorylation of GSK3α and β subunits, protects cells from oxidative stress-induced cell death, and suppresses cytokine release in response to pro-inflammatory stimuli in microglia.
- Inhibits TRPM2 in cells (IC50=100 nM chimpanzee, 25 nM rat, 126 nM human)
- Prevents cells from H2O2 induced cell death up to 1 mM of H2O2
- Protects HeLa cells from H2O2 induced morphological changes
- Brain penetrant and achieves 400 ng/mL in the brain compartment
Cayman Chemical ANTIBODY MI-192 10mg
An HDAC inhibitor that preferentially inhibits HDAC2 (IC50 = 30 nM) and HDAC3 (IC50 = 16 nM) over HDAC1, 4, 6, 7, and 8 (IC50s = 4.8, 5, >10, 4.1, and >10 μM, respectively).{29271} At 0.1-0.4 μM, it induces differentiation and promotes apoptosis of acute myeloid leukemic cell lines U937, HL60, and Kasumi-1
Medchemexpress LLC Rotenolone | 509-96-6 | 97.0% | 50 MG
Rotenolone is an antiproliferative small molecule (CAS 509-96-6) supplied as a powder for research use. It is reported at 97.0% purity, with molecular formula C23H22O7 and molecular weight 410.42 g·mol-1. See product documentation for solubility, storage, and safety data.
- Antiproliferative small molecule suitable for in vitro research.
- CAS 509-96-6 and common synonym 12alpha-hydroxyrotenone.
- Purity 97.0%.
- Molecular formula C23H22O7; molecular weight 410.42 g·mol-1.
- Available as a powder, common vial sizes include 50 MG.
- Soluble in DMSO (100 mg/mL); in vivo formulations documented.
- Store powder at -20°C; store solutions at -80°C (6 months) or -20°C (1 month).